← GUMP
Research
Computational results. Real data. Open methods. All on one Mac Mini.
GPU fold engine: 8,700,000 proteins/sec | Mutation scanner: 362,000/sec
Compute: 17.69 TFLOPS (GPU + ANE) | Hardware: Mac Mini M4, $499, 35W
Tests: 673 quality tests, 0 failures | Reproducible: pip install begump
Latest
The Map — Everything Under K
Interactive visualization of the biological blueprint. 8 levels from constants to physics. 10 proved, 11 killed, everything honest. The coupling ceiling, the fixed point, the regulator, the breathing.
10 proved live visualization April 2026
Mutation Scanner + T-Profiler — 25 Disease Proteins
GPU-accelerated variant pathogenicity screening. 362,000 mutations/sec. T = K − R tension framework with drug strategy. 83% accuracy on 56 variants (MM9P validated), 88% precision, 15 physics-based signals. No MSA. No PDB. Sequence and coupling only.
83% MM9P validated T = K − R framework drug strategy April 2026
Medicine & Disease
Amyloid-beta 42 — Alzheimer's Disease
Engine independently found the tramiprosate (Phase 3) strategy: add charge at KLVFF position 18. V18D reduces aggregation 28%, increases helix 31%→45%. Double mutation F19D+I32R reduces aggregation 50%.
25/26 verified matches clinical trial double mutations
FUS Prion Domain — ALS
Opposite strategy: hydrophobic mutations create a core that never existed. Titrated to 2-anchor minimum effective dose. A brace, not a cast. Crosslinker molecule designed.
6/6 verified crosslinker designed
Alpha-Synuclein — Parkinson's Disease
V70D at center of NAC aggregation core reduces aggregation by 7 residues. Same charge strategy as Alzheimer's. Charge universally reduces amyloid in 4/5 tested diseases.
4/5 diseases universal rule
IAPP — Type 2 Diabetes Amyloid
Charge at F15-L16 reduces amyloid nucleation 50%, creates helix from nothing. New peptide mimetic designed from mutation data.
3/3 verified new molecule
Coming: full ClinVar validation · PDB fragment library · conservation integration · ribosome-mode birth trajectories
Cancer
Cancer Signaling Pathway Engine
11 proteins, 15 directed edges, 9 cancers modeled. Drug combo simulation: sotorasib + APR-246 restores 84% of pancreatic cancer pathway to healthy.
coming soon 9 cancers · 21ms per patient analysis
Drug Interaction Screening
19,600 interactions of the top 49 prescribed drugs in America. 11,298 hazards identified. CYP450 competition model. Patient-specific "which drug to remove."
all known dangerous flagged all known safe passed 118ms
Coming: complete mutation landscapes · double mutation screening · resistance prediction · combination therapy optimization
Materials & Energy
Battery Cathode Screening
50,000 NMC cathode compositions ranked by structural stability and ion diffusion. Stiffness engine discriminates best from worst.
coming soon 795K structures/sec · 15ms
Perovskite Solar Cell Screening
20,000 perovskite ABX3 structures evaluated. A-site mixing, B-site doping, X-site halide ratios all explored.
coming soon 642K structures/sec
Coming: superconductor candidates · carbon capture molecules · catalyst design
Finance & Fraud
Financial Crime Detection
Backtested against Enron, Madoff, Wirecard, FTX, and Danske Bank. 5/5 fraud patterns detected. 2/3 clean structures passed cleanly. 1 borderline flag (supply chain complexity resembles fraud layering — honest limit).
5/5 fraud · 7/8 overall
Coming: cryptocurrency forensics · insider trading patterns · market microstructure
Security
Behavioral Threat Detection
30/30 attack scenarios detected including cryptominers, ransomware, DDoS, time bombs, and evasion attempts. Self-monitoring detects its own corruption at 3.3σ.
coming soon 30/30 attacks
Coming: zero-day pattern analysis · lateral movement detection · supply chain risk
Computation
Shape Computing — Prime Bounce Dispatch
Prime-spaced escalating dispatch (2,3,5,7 × 2 × 3) achieves 9.12x throughput gain on GPU. Ghost cores: command queue interference creates real computation. The chip's hardware IS prime-factored.
9.12x measured new technique 428K→3.9M/sec
Reversible Computing — Energy Floor
Mac Mini M4 operates 340M× above Landauer limit. Reversible Toffoli gates verified correct. Prime-scheduled adiabatic switching models energy recirculation.
coming soon adder verified 9/9
Coming: persistent Metal kernel architecture · ANE classifier pipeline · universal stiffness engine
Education
Grokking Detection
Phase transition from memorization to understanding detected in student performance data and ML training runs. 19,716 inferences/sec on Neural Engine.
coming soon
Coming: curriculum optimization · knowledge gap mapping · learning rate adaptation
Legal & Compliance
Regulatory Gap Analysis
Automated compliance gap detection from regulation text. Action plans with priorities. Counter-strategies generated.
coming soon
Coming: cross-jurisdiction conflict detection · regulatory change tracking
All research computed on Mac Mini M4, 16GB unified memory, 35W. Shape computing engine: 3.9M analyses/sec, 459 bytes per protein, prime bounce dispatch. Code: pip install begump